Effect of Antidepressant Switching vs Augmentation on Remission Among Patients With Major Depressive Disorder Unresponsive to Antidepressant Treatment

Mohamed, Somaia; R. Johnson, Gary; Chen, Peijun; B. Hicks, Paul; L. Davis, Lori; Yoon, Jean; Gleason, Theresa; E. Vertrees, Julia; Weingart, Kimberly; Tal, Ilanit; Scrymgeour, Alexandra; Lawrence, David; Planeta, Beata; E. Thase, Michael; D. Huang, Grant; Zisook, Sidney; the VAST-D Investigators, and; Rao, Sanjai; Pilkinton, Patricia; A. Wilcox, James; Iranmanesh, Ali; Sapra, Mamta; Jurjus, George; P. Michalets, James; Aslam, Muhammed; P. Beresford, Thomas; D. Anderson, Keith; Fernando, Ronald; Ramaswamy, Sriram; Kasckow, John; Westermeyer, Joseph; Yoon, Gihyun; Cyril D’Souza, Deepak; Larson, Gunnar; Gary Anderson, W.; M. Klatt, Mary; Fareed, Ayman; I. Thompson, Shabnam; J. Carrera, Carlos; S. Williams, Solomon; Juergens, Timothy; J. Albers, Lawrence; S. Nasdahl, Clifford; Villarreal, Gerardo; L. Winston, Julia; A. Nogues, Cristobal; Ryan Connolly, K.; Tapp, André; Jones, Kari; Khatkhate, Gauri; Marri, Sheetal; Suppes, Trisha; M. LaMotte, Joseph; A. Hurley, Robin; R. Mayeda, Aimee; B. Niculescu, Alexander; A. Fischer, Bernard; Loreck, David; Rosenlicht, Nicholas; P. Lieske, Steven; S. Finkel, Mitchell; T. Little, John

doi:10.1001/jama.2017.8036

Public

Effect of Antidepressant Switching vs Augmentation on Remission Among Patients With Major Depressive Disorder Unresponsive to Antidepressant Treatment

Published in JAMA • Jul 11, 2017

Authors:

Somaia Mohamed

Gary R. Johnson

Peijun Chen

Abstract

IMPORTANCE: Less than one-third of patients with major depressive disorder (MDD) achieve remission with their first antidepressant. OBJECTIVE: To determine the relative effectiveness and safety of 3 common alternate treatments for MDD. DESIGN, SETTING, AND PARTICIPANTS: From December 2012 to May 201...

Subject

Medicine

Bupropion

Aripiprazole

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