Pan-mTOR inhibitor MLN0128 is effective against intrahepatic cholangiocarcinoma in mice

Zhang, Shanshan; Song, Xinhua; Cao, Dan; Xu, Zhong; Fan, Biao; Che, Li; Hu, Junjie; Chen, Bin; Dong, Mingjie; G. Pilo, Maria; Cigliano, Antonio; Evert, Katja; Ribback, Silvia; Dombrowski, Frank; M. Pascale, Rosa; Cossu, Antonio; Vidili, Gianpaolo; Porcu, Alberto; M. Simile, Maria; Mario Pes, Giovanni; Giannelli, Gianluigi; D. Gordan, John; Wei, Lixin; Evert, Matthias; Cong, Wen‐Ming; F. Calvisi, Diego; Chen, Xin

doi:10.1016/j.jhep.2017.07.006

Public

Pan-mTOR inhibitor MLN0128 is effective against intrahepatic cholangiocarcinoma in mice

Published in Journal of Hepatology • Jul 19, 2017

Authors:

Shanshan Zhang

Xinhua Song

Dan Cao

Abstract

BACKGROUND & AIMS: Intrahepatic cholangiocarcinoma (ICC) is a lethal malignancy without effective treatment options. MLN0128, a second generation pan-mTOR inhibitor, shows efficacy for multiple tumor types. We evaluated the therapeutic potential of MLN0128 vs. gemcitabine/oxaliplatin in a novel ICC ...

Subject

Protein kinase B

Oxaliplatin

mTORC1

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