Pan-mTOR inhibitor MLN0128 is effective against intrahepatic cholangiocarcinoma in mice

Zhang, Shanshan; Song, Xinhua; Cao, Dan; Xu, Zhong; Fan, Biao; Che, Li; Hu, Junjie; Chen, Bin; Dong, Mingjie; G. Pilo, Maria; Cigliano, Antonio; Evert, Katja; Ribback, Silvia; Dombrowski, Frank; M. Pascale, Rosa; Cossu, Antonio; Vidili, Gianpaolo; Porcu, Alberto; M. Simile, Maria; Mario Pes, Giovanni; Giannelli, Gianluigi; D. Gordan, John; Wei, Lixin; Evert, Matthias; Cong, Wen‐Ming; F. Calvisi, Diego; Chen, Xin

doi:10.1016/j.jhep.2017.07.006

Public

Pan-mTOR inhibitor MLN0128 is effective against intrahepatic cholangiocarcinoma in mice

Published in Journal of Hepatology • Jul 19, 2017

Authors:

Shanshan Zhang

Xinhua Song

Dan Cao

Abstract

•A novel mouse model of intrahepatic cholangiocarcinoma (ICC) was established.•Hydrodynamic transfection of activated forms of AKT and Yap was used to induce ICC.•This model recapitulates many morphological and molecular features of human ICC.•MLN0128 may be superior to gemcitabine/oxaliplatin based...

Subject

Protein kinase B

Oxaliplatin

mTORC1

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