MicroRNA-100 shuttled by mesenchymal stem cell-derived exosomes suppresses in vitro angiogenesis through modulating the mTOR/HIF-1α/VEGF signaling axis in breast cancer cells

Pakravan, Katayoon; Babashah, Sadegh; Sadeghizadeh, Majid; Javad Mowla, Seyed; Mossahebi‐Mohammadi, Majid; Ataei, Farangis; Dana, Nasim; Javan, Mohammad

doi:10.1007/s13402-017-0335-7

Public

MicroRNA-100 shuttled by mesenchymal stem cell-derived exosomes suppresses in vitro angiogenesis through modulating the mTOR/HIF-1α/VEGF signaling axis in breast cancer cells

Published in Cellular Oncology • Jul 24, 2017

Authors:

Katayoon Pakravan

Sadegh Babashah

Majid Sadeghizadeh

Abstract

BACKGROUND: Human mesenchymal stem cells (MSCs) have been shown to be involved in the formation and modulation of tumor stroma and in interacting with tumor cells, partly through their secretome. Exosomes are nano-sized intraluminal multi-vesicular bodies secreted by most types of cells and have bee...

Subject

Microvesicles

Angiogenesis

Mesenchymal stem cell

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