A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma | NobleBlocks
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A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma
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Shared by NobleBlocks on Jul 19, 2017 • 12:00 AM UTC
Authors:
Donald M. O’Rourke
,
MacLean P. Nasrallah
,
Arati Desai
Abstract
A trial of autologous T cells redirected to a specific mutation in glioblastoma patients illustrates mechanisms of resistance.
