Single-Cell RNA-Seq Analysis of Infiltrating Neoplastic Cells at the Migrating Front of Human Glioblastoma

Darmanis, Spyros; A. Sloan, Steven; Croote, Derek; Mignardi, Marco; B. Chernikova, Sophia; Samghababi, Peyman; Zhang, Ye; Neff, Norma; Kowarsky, Mark; Caneda, Christine; Li, Gordon; D. Chang, Steven; D. Connolly, Ian; Li, Yingmei; A. Barres, Ben; Hayden Gephart, Melanie; R. Quake, Stephen

doi:10.1016/j.celrep.2017.10.030

Public

Single-Cell RNA-Seq Analysis of Infiltrating Neoplastic Cells at the Migrating Front of Human Glioblastoma

Published in Cell Reports • Oct 1, 2017

Authors:

Spyros Darmanis

Steven A. Sloan

Derek Croote

Abstract

Glioblastoma (GBM) is the most common primary brain cancer in adults and is notoriously difficult to treat because of its diffuse nature. We performed single-cell RNA sequencing (RNA-seq) on 3,589 cells in a cohort of four patients. We obtained cells from the tumor core as well as surrounding periph...

Subject

Glioblastoma

RNA-Seq

RNA

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