Anti-Vascular Endothelial Growth Factors Protect Retinal Pigment Epithelium Cells Against Oxidation by Modulating Nitric Oxide Release and Autophagy

De Cillà, Stefano; Farruggio, Serena; Vujosevic, Stela; Raina, Giulia; Filippini, Davide; Gatti, Valentina; Clemente, Nausicaa; Mary, David; Vezzola, Diego; Casini, Giamberto; Rossetti, Luca; Grossini, Elena

doi:10.1159/000479441

Public

Anti-Vascular Endothelial Growth Factors Protect Retinal Pigment Epithelium Cells Against Oxidation by Modulating Nitric Oxide Release and Autophagy

Published in Cellular Physiology and Biochemistry • Jan 1, 2017

Authors:

Stefano De Cillà

Serena Farruggio

Stela Vujosevic

Abstract

BACKGROUND/AIMS: the anti-vascular endothelial growth factors (VEGF), Aflibercept and Ranibizumab, are used for the treatment of macular degeneration. Here we examined the involvement of nitric oxide (NO), mitochondria function and of apoptosis/autophagy in their antioxidant effects in human retinal...

Subject

Retinal pigment epithelium

Occludin

Tight junction

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