The liver-enriched lnc-LFAR1 promotes liver fibrosis by activating TGFβ and Notch pathways

Zhang, Kun; Han, Xiaohui; Zhang, Zhen; Zheng, Lina; Hu, Zhimei; Yao, Qingbin; Cui, Hongmei; Shu, Guiming; Si, Maojie; Li, Chan; Shi, Zhemin; Chen, Ting; Han, Yawei; Chang, Yanan; Yao, Zhi; Han, Tao; Wei, Hong

doi:10.1038/s41467-017-00204-4

Public

The liver-enriched lnc-LFAR1 promotes liver fibrosis by activating TGFβ and Notch pathways

Published in Nature Communications • Jul 19, 2017

Authors:

Kun Zhang

Xiaohui Han

Zhen Zhang

Abstract

- and bile duct ligation-induced liver fibrosis in mice. Lnc-LFAR1 promotes the binding of Smad2/3 to TGFβR1 and its phosphorylation in the cytoplasm. Lnc-LFAR1 binds directly to Smad2/3 and promotes transcription of TGFβ, Smad2, Smad3, Notch2 and Notch3 which, in turn, results in TGFβ and Notch pat...

Subject

Hepatic stellate cell

Notch signaling pathway

Cell biology

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