Exosomes containing miR-21 transfer the characteristic of cisplatin resistance by targeting PTEN and PDCD4 in oral squamous cell carcinoma

Liu, Tao; Chen, Gang; Sun, Dawei; Lei, Minghui; Li, Yongqiang; Zhou, Changming; Li, Xiaodong; Xue, Wei; Wang, Hong; Liu, Chunjun; Xu, Jiang

doi:10.1093/abbs/gmx078

Public

Exosomes containing miR-21 transfer the characteristic of cisplatin resistance by targeting PTEN and PDCD4 in oral squamous cell carcinoma

Published in Acta Biochimica et Biophysica Sinica • Jul 10, 2017

Authors:

Tao Liu

Gang Chen

Dawei Sun

Abstract

Resistance to chemotherapy remains a major obstacle for the effective treatment of oral squamous cell carcinoma (OSCC). Evidence for the involvement of exosomes as important regulators of cisplatin chemoresistance in OSCC is still poorly understood. Our objective of this study was to explore the rol...

Subject

Microvesicles

Cisplatin

Cancer research

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