The IMPROVE Guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments)

Percie du Sert, Nathalie; Alfieri, Alessio; M. Allan, Stuart; Carswell, H; A. Deuchar, Graeme; D. Farr, Tracy; Flecknell, Paul; Gallagher, Lindsay; L. Gibson, Claire; Haley, Michael; Macleod, Malcolm; W. McColl, Barry; McCabe, Christopher; Morancho, Anna; Moon, Lawrence; J. O’Neill, Michael; Pérez de Puig, Isabel; M. Planas, Anna; Ragan, Chikako; Rosell, Anna; A. Roy, Lisa; Ryder, Kathy; Simats, Alba; S. Sena, Emily; A. Sutherland, Brad; D. Tricklebank, Mark; C. Trueman, Rebecca; Whitfield, Lucy; Wong, Raymond; Mhairi Macrae, I.

doi:10.1177/0271678x17709185

Public

The IMPROVE Guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments)

Published in Journal of Cerebral Blood Flow & Metabolism • Aug 11, 2017

Authors:

Nathalie Percie du Sert

Alessio Alfieri

Stuart M. Allan

Abstract

Most in vivo models of ischaemic stroke target the middle cerebral artery and a spectrum of stroke severities, from mild to substantial, can be achieved. This review describes opportunities to improve the in vivo modelling of ischaemic stroke and animal welfare. It provides a number of recommendatio...

Subject

Stroke (engine)

Medicine

Ischemia

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