First-line selective internal radiotherapy plus chemotherapy versus chemotherapy alone in patients with liver metastases from colorectal cancer (FOXFIRE, SIRFLOX, and FOXFIRE-Global): a combined analysis of three multicentre, randomised, phase 3 trials

Wasan, Harpreet; Gibbs, Peter; Sharma, Navesh; Taı̈eb, Julien; Heinemann, Volker; Ricke, Jens; Peeters, Marc; Findlay, Michael; Weaver, Andrew; Mills, Jamie; Wilson, Charles; Adams, Richard; Francis, Anne; Moschandreas, Joanna; S. Virdee, Pradeep; Dutton, Peter; Love, Sharon; Gebski, Val; Gray, Alastair; Adams, Richard; Bateman, Andrew; Blesing, Claire; Brown, Ewan; Chau, Ian; Cummins, Sebastian; Cunningham, David; Falk, Stephen; Hadaki, Maher; Hall, Marcia; Hickish, Tamas; Hornbuckle, Joanne; Lofts, F.; Lowndes, Sarah; Mayer, Astrid; S. Metcalfe, Matthew; Middleton, Gary; Mills, Jamie; Montazeri, Amir; Muirhead, R.; Polychronis, Andreas; Purcell, Colin; J. Ross, Paul; A. Sharma, Ricky; Sherwin, Liz; Smith, David; Soomal, Rubin; Swinson, Daniel; Walther, Axel; Wasan, Harpreet; Weaver, Andrew; Wilson, Charles; Wilson, Greg; Amin, Pradip; Angelelli, Bruna; Balosso, Jacques; Beny, Alex; Bloomgarden, Daniel; Boucher, Evelyn; D. Brown, Michael; Bruch, Harald-Robert; Bui, James; Burge, Matthew; Cardaci, Giuseppe; Carlisle, James; Chai, Seungjean; Chen, Yi‐Jen; Chevallier, P.; Chuong, Michael; Clarke, Stephen; L. Coveler, Andrew; Craninx, M; Delanoit, Thierry; Deleporte, Amélie; Eliadis, Paul; Facchini, Francis; W. Ferguson, Thomas; Ferrante, Michel; Findlay, Michael; Frenette, Gary; Frick, Jacob; Ganju, Vinod; Garofalo, Michael; Geboes, Karen; Gehbauer, Gerald; George, Benjamin; Geva, Ravit; Gibbs, Peter; A. Gordon, Melita; Gregory, Kate; A. Güleç, Seza; Hannigan, James; van Hazel, Guy; Heching, Norman; Heinemann, Volker; Helmberger, Thomas; Hendlisz, Alain; Hendrickx, Koen; P. Holtzman, Matthew; Isaacs, Richard; Jackson, Christopher; E. James, Philip; Kaiser, Adeel; S. Karapetis, Christos; Kaubisch, Andreas; Ko, Yon-Dschun; Kröning, H.; Lammert, Frank; Liauw, Winston; Limentani, Steven; Louafi, Samy; De Man, Marc; Margolis, Jeffrey; N. Martin, Robert; Martoni, Andrea; Marx, Gavin; Matos, Marco; Monsaert, Els; Moons, Veerle; Nott, Louise; Nusch, Arnd; O’Donnell‐Luria, Anne; Ozer, Howard; Padia, Siddarth; Pavlakis, Nick; Peeters, Marc; Díaz Pérez, D; Pluntke, Stefan; Polus, Marc; Powell, Alex; Pracht, Marc; Price, Timothy; Ransom, David; Rebischung, Christine; Ricke, Jens; Ridwelski, Karsten; Riera‐Knorrenschild, Jorge; Riess, Hanno; S. Rilling, William; A. Robinson, Bridget; Rodríguez, Javier; Augusto Sanchez, Federico; Sauerbruch, Tilmann; A. Savin, Michael; Scheidhauer, Klemens; Schneiderman, Elyse; R. Seeger, Grant; Segelov, Eva; Shaham Schmueli, Einat; Shani, Adi; Shannon, Jenny; Sharma, Navesh; Shibata, Stephen; Singhal, Nimit; Smith, Denis; Smith, Randall; M. Stemmer, Salomon; Stötzer, Oliver; Strickland, Andrew; Taı̈eb, Julien; Tatsch, Klaus; Terrebonne, Eric; Tichler, Thomas; Vehling‐Kaiser, Ursula; Vera, Ruth; Vogl, Thomas; Walpole, Euan; W. Wang, Eric; H. Whiting, Samuel; Wolf, Ido; Ades, Steven; Aghmesheh, Morteza; Angelelli, Bruna; Auber, Miklos; Ayala, Hubert; Beny, Alex; Bloomgarden, Daniel; A. Boland, Patrick; Bouche, Eveline; Bowers, Charles; Bremer, Christoph; Bui, James; Burge, Mathew; Carlisle, James; Ruiz‐Casado, Ana; Chai, Seungjean; Chuong, Michael; Cooray, Prasad; Christ Crain, M; de Wit, Maike; Dowling, Kyran; Durand, Aurélie; Facchini, Francis; Faivre, Sandrine; Feeney, Kynan; Ferguson, Tom; Ferru, Aurélie; Findlay, Michael; Candida Barisson Villares Fragoso, Maria; Frenette, Gary; Frick, Jacob; Ganju, Vinod; Geva, Ravit; Gibbs, Peter; Granetto, Cristina; Hammel, Pascal; van Hazel, Guy; Heching, Norman; Hendlisz, Alain; Hendrickx, Koen; P. Holtzman, Matthew; Issacs, Richard; Iyer, Renuka; Jackson, Christopher; Kaiser, Adeel; Kaubisch, Andreas; Hong Kim, Yeul; Kröning, H.; Liang, Jin‐Tung; Lim, Lionel; Limentani, Steven; H, Liu; Louafi, Samy; De Man, Marc; Masi, Gianluca; Matos, Marco; Monsaert, Els; Mosconi, Stefania; Nott, Louise; Numico, Gianmauro; O’Donnell‐Luria, Anne; Peeters, Marc; Polus, Marc; Pracht, Marc; Ratner, Lynn; Rebischung, Christine; Han, Sae‐Won; Augusto Sanchez, Federico; Shani, Adi; Sharma, Navesh; Singh, Madhu; Singhal, Nimit; Smith, Denis; Stoltzfus, Patricia; Strickland, Andrew; Taı̈eb, Julien; Tan, Iain; Terrebonne, Eric; Tichler, Thomas; Trogu, Antonio; Underhill, Craig; Vera, Ruth; Walpole, Euan; W. Wang, Eric; Westcott, Mark; van Hazel, Guy; A. Sharma, Ricky

doi:10.1016/s1470-2045(17)30457-6

Public

First-line selective internal radiotherapy plus chemotherapy versus chemotherapy alone in patients with liver metastases from colorectal cancer (FOXFIRE, SIRFLOX, and FOXFIRE-Global): a combined analysis of three multicentre, randomised, phase 3 trials

Published in The Lancet Oncology • Aug 3, 2017

Authors:

Harpreet Wasan

Peter Gibbs

Navesh Sharma

Abstract

BACKGROUND: Data suggest selective internal radiotherapy (SIRT) in third-line or subsequent therapy for metastatic colorectal cancer has clinical benefit in patients with colorectal liver metastases with liver-dominant disease after chemotherapy. The FOXFIRE, SIRFLOX, and FOXFIRE-Global randomised s...

Subject

Oxaliplatin

FOLFOX

Medicine

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