Pomegranate ellagitannin-gut microbial-derived metabolites, urolithins, inhibit neuroinflammation <i>in vitro</i>

A. DaSilva, Nicholas; Nahar, Pragati; Ma, Hang; Eid, Aseel; Wei, Zhengxi; Meschwitz, Susan; H. Zawia, Nasser; L. Slitt, Angela; P. Seeram, Navindra

doi:10.1080/1028415x.2017.1360558

Public

Pomegranate ellagitannin-gut microbial-derived metabolites, urolithins, inhibit neuroinflammation in vitro

Published in Nutritional Neuroscience • Aug 7, 2017

Authors:

Nicholas A. DaSilva

Pragati Nahar

Hang Ma

Abstract

Objectives: Urolithins, ellagitannin-gut microbial-derived metabolites, have been reported to mediate pomegranate’s neuroprotective effects against Alzheimer’s disease (AD), but there are limited data on their effects against neuroinflammation. Herein, we: (1) evaluated whether urolithins (urolithin...

Subject

Neuroinflammation

Oxidative stress

Pharmacology

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