Chemogenetics revealed: DREADD occupancy and activation via converted clozapine

L. Gomez, Juan; Bonaventura, Jordi; G. Lesniak, Wojciech; B. Mathews, William; Sysa‐Shah, Polina; A. Rodriguez, Lionel; J. Ellis, Randall; T. Richie, Christopher; K. Harvey, Brandon; F. Dannals, Robert; G. Pomper, Martin; Bonci, Antonello; Michaelides, Michael

doi:10.1126/science.aan2475

Public

Chemogenetics revealed: DREADD occupancy and activation via converted clozapine

Published in Science • Aug 3, 2017

Authors:

Juan L. Gomez

Jordi Bonaventura

Wojciech G. Lesniak

Abstract

The chemogenetic technology DREADD (designer receptors exclusively activated by designer drugs) is widely used for remote manipulation of neuronal activity in freely moving animals. DREADD technology posits the use of "designer receptors," which are exclusively activated by the "designer drug" cloza...

Subject

Receptor

Clozapine

Neuroscience

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