CD163-positive tumor-associated macrophages and CD8-positive cytotoxic lymphocytes are powerful diagnostic markers for the therapeutic stratification of osteosarcoma patients: An immunohistochemical analysis of the biopsies fromthe French OS2006 phase 3 trial

Gomez‐Brouchet, Anne; Illac, Claire; Gilhodes, Julia; Bouvier, Corinne; Aubert, Sébastien; Guinebretière, Jean‐Marc; Marie, Béatrice; Larousserie, Fréderique; Entz‐Werlé, Natacha; de Pinieux, Gonzague; Filleron, Thomas; Minard‐Colin, Véronique; Minville, Vincent; Mascard, Éric; Gouin, F.; Jimenez, Marta; Ledeley, Marie-cecile; Piperno‐Neumann, Sophie; Brugières, Laurence; Rédiní, Françoise

doi:10.1080/2162402x.2017.1331193

Public

CD163-positive tumor-associated macrophages and CD8-positive cytotoxic lymphocytes are powerful diagnostic markers for the therapeutic stratification of osteosarcoma patients: An immunohistochemical analysis of the biopsies fromthe French OS2006 phase 3 trial

Published in OncoImmunology • Aug 24, 2017

Authors:

Anne Gomez‐Brouchet

Claire Illac

Julia Gilhodes

Abstract

The French phase 3 trial (OS 2006) testing zoledronic acid, an osteoclast inhibitor, with chemotherapy and surgery did not improve the outcome of patients with osteosarcoma (OS). To understand this unexpected result, the presence of infiltrating immune cells was investigated in 124 pre-therapeutic b...

Subject

CD163

CD68

Medicine

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