Genomic Evolution of Breast Cancer Metastasis and Relapse

Yates, Lucy; Knappskog, Stian; C. Wedge, David; H. R. Farmery, James; González, Santiago; Martincorena, Iñigo; B. Alexandrov, Ludmil; Van Loo, Peter; Kristian Haugland, Hans; Kaare Lilleng, Peer; Gundem, Gunes; Gerstung, Moritz; Pappaemmanuil, Elli; Gazińska, Patrycja; G. Bhosle, Shriram; Jones, David; Raine, Keiran; Mudie, Laura; Latimer, Calli; J. Sawyer, Elinor; Desmedt, Christine; Sotiriou, Christos; R. Stratton, Michael; M. Sieuwerts, Anieta; G. Lynch, Andy; W.M. Martens, John; L. Richardson, Andrea; Tutt, Andrew; Eystein Lønning, Per; J. Campbell, Peter

doi:10.1016/j.ccell.2017.07.005

Public

Genomic Evolution of Breast Cancer Metastasis and Relapse

Published in Cancer Cell • Aug 1, 2017

Authors:

Lucy Yates

Stian Knappskog

David C. Wedge

Abstract

Patterns of genomic evolution between primary and metastatic breast cancer have not been studied in large numbers, despite patients with metastatic breast cancer having dismal survival. We sequenced whole genomes or a panel of 365 genes on 299 samples from 170 patients with locally relapsed or metas...

Subject

Breast cancer

Metastasis

Primary tumor

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