Dynamic causal modeling in PTSD and its dissociative subtype: Bottom–up versus top–down processing within fear and emotion regulation circuitry

A. Nicholson, Andrew; Friston, Karl; Zeidman, Peter; Harricharan, Sherain; C. McKinnon, Margaret; Densmore, Maria; W. J. Neufeld, Richard; Théberge, Jean; M. Corrigan, Frank; Jetly, Rakesh; Spiegel, David; A. Lanius, Ruth

doi:10.1002/hbm.23748

Public

Dynamic causal modeling in PTSD and its dissociative subtype: Bottom–up versus top–down processing within fear and emotion regulation circuitry

Published in Human Brain Mapping • Aug 24, 2017

Authors:

Andrew A. Nicholson

Karl Friston

Peter Zeidman

Abstract

OBJECTIVE: Posttraumatic stress disorder (PTSD) is associated with decreased top-down emotion modulation from medial prefrontal cortex (mPFC) regions, a pathophysiology accompanied by hyperarousal and hyperactivation of the amygdala. By contrast, PTSD patients with the dissociative subtype (PTSD + D...

Subject

Amygdala

Ventromedial prefrontal cortex

Psychology

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!