Dynamic causal modeling in PTSD and its dissociative subtype: Bottom–up versus top–down processing within fear and emotion regulation circuitry

A. Nicholson, Andrew; J. Friston, Karl; Zeidman, Peter; Harricharan, Sherain; C. McKinnon, Margaret; Densmore, Maria; W.J. Neufeld, Richard; Théberge, Jean; Corrigan, Frank; Jetly, Rakesh; Spiegel, David; A. Lanius, Ruth

doi:10.1002/hbm.23748

Public

Dynamic causal modeling in PTSD and its dissociative subtype: Bottom–up versus top–down processing within fear and emotion regulation circuitry

Shared by NobleBlocks on Aug 24, 2017 • 12:00 AM UTC

Authors:

Andrew A. Nicholson

Karl J. Friston

Peter Zeidman

Abstract

Abstract Objective Posttraumatic stress disorder (PTSD) is associated with decreased top–down emotion modulation from medial prefrontal cortex (mPFC) regions, a pathophysiology accompanied by hyperarousal and hyperactivation of the amygdala. By contrast, PTSD patients with the dissociative subtype (...

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