Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

M. Ridker, Paul; M. Everett, Brendan; Thurén, Tom; MacFadyen, Jean; H. Chang, William; M. Ballantyne, Christie; Antônio Helfenstein Fonseca, Francisco; Carlos Nicolau, José; Köenig, Wolfgang; D. Anker, Stefan; J.P. Kastelein, John; H. Cornel, Jan; Pais, Prem; Pella, Daniel; Genest, Jacques; Cífková, Renata; Lorenzatti, Alberto; Forster, Tamás; Kobalava, Zhanna; Vida-Simiti, L; Flather, Marcus; Shimokawa, Hiroaki; Ogawa, Hisao; Dellborg, Mikael; R.F. Rossi, Paulo; P.T. Troquay, Roland; Libby, Peter; J. Glynn, Robert

doi:10.1056/nejmoa1707914

Public

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

Published in New England Journal of Medicine • Aug 27, 2017

Authors:

Paul M. Ridker

Brendan M. Everett

Tom Thurén

Abstract

BACKGROUND: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. METHODS: We conducted a randomized, double-blind trial of canakinuma...

Subject

Canakinumab

Medicine

Placebo

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