Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-β1/Smads and PI3K/Akt pathways

Wu, Liwei; Zhang, Qinghui; Mo, Wenhui; Feng, Jiao; Li, Sainan; Li, Jingjing; Liu, Tong; Xu, Shizan; Wang, Wenwen; Lu, Xiya; Yu, Qiang; Chen, Kan; Xia, Yujing; Lu, Jie; Xu, Ling; Zhou, Yingqun; Fan, Xiaoming; Guo, Chuanyong

doi:10.1038/s41598-017-09673-5

Public

Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-β1/Smads and PI3K/Akt pathways

Published in Scientific Reports • Aug 18, 2017

Authors:

Liwei Wu

Qinghui Zhang

Wenhui Mo

Abstract

Abstract The aim of this study was to investigate the effect of quercetin on hepatic fibrosis, a characteristic response to acute or chronic liver injury. Mice were randomized to bile duct ligation (BDL) or carbon tetrachloride (CCl 4 ) cirrhosis models. Quercetin (100 mg/kg or 200 mg/kg daily) was ...

Subject

Hepatic stellate cell

PI3K/AKT/mTOR pathway

Hepatic fibrosis

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