miR-145-5p Suppresses Tumor Cell Migration, Invasion and Epithelial to Mesenchymal Transition by Regulating the Sp1/NF-κB Signaling Pathway in Esophageal Squamous Cell Carcinoma

Mei, Li‐Li; Wang, Wenjun; Qiu, Yuntan; Xie, Xiufeng; Bai, Jie; Shi, Zhi‐Zhou

doi:10.3390/ijms18091833

Public

miR-145-5p Suppresses Tumor Cell Migration, Invasion and Epithelial to Mesenchymal Transition by Regulating the Sp1/NF-κB Signaling Pathway in Esophageal Squamous Cell Carcinoma

Published in International Journal of Molecular Sciences • Aug 23, 2017

Authors:

Li‐Li Mei

Wenjun Wang

Yuntan Qiu

Abstract

MicroRNAs (miRNAs) play important roles in the progression of human cancer. Although previous reports have shown that miR-145-5p is down-regulated in esophageal squamous cell carcinoma (ESCC), the roles and mechanisms of down-regulation of miR-145-5p in ESCC are still largely unknown. Using microRNA...

Subject

Epithelial–mesenchymal transition

Gene knockdown

Cyclin D1

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