Fibroblast-specific TGF-β–Smad2/3 signaling underlies cardiac fibrosis

Khalil, Hadi; Kanisicak, Onur; Prasad, Vikram; N. Correll, Robert; Fu, Xing; G. Schips, Tobias; J. Vagnozzi, Ronald; Liu, Ruijie; V. Huynh, Thanh; Lee, Se‐Jin; Karch, Jason; D. Molkentin, Jeffery

doi:10.1172/jci94753

Public

Fibroblast-specific TGF-β–Smad2/3 signaling underlies cardiac fibrosis

Published in Journal of Clinical Investigation • Sep 10, 2017

Authors:

Hadi Khalil

Onur Kanisicak

Vikram Prasad

Abstract

The master cytokine TGF-β mediates tissue fibrosis associated with inflammation and tissue injury. TGF-β induces fibroblast activation and differentiation into myofibroblasts that secrete extracellular matrix proteins. Canonical TGF-β signaling mobilizes Smad2 and Smad3 transcription factors that co...

Subject

Fibrosis

Cardiac fibrosis

Fibroblast

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