Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models

Cekanaviciute, Egle; B. Yoo, Bryan; F. Runia, Tessel; W. Debelius, Justine; Singh, Sneha; Nelson, Charlotte; Kanner, Rachel; Bencosme, Yadira; Kyung Lee, Yun; L. Hauser, Stephen; Crabtree‐Hartman, Elizabeth; Katz Sand, Ilana; Gacias, Mar; Zhu, Yunjiao; Casaccia, Patrizia; Cree, Bruce; Knight, Rob; K. Mazmanian, Sarkis; E. Baranzini, Sergio

doi:10.1073/pnas.1711235114

Public

Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models

Published in Proceedings of the National Academy of Sciences • Sep 11, 2017

Authors:

Egle Cekanaviciute

Bryan B. Yoo

Tessel F. Runia

Abstract

Significance We have experimentally investigated the immunoregulatory effects of human gut microbiota in multiple sclerosis (MS). We have identified specific bacteria that are associated with MS and demonstrated that these bacteria regulate T lymphocyte-mediated adaptive immune responses and contrib...

Subject

Experimental autoimmune encephalomyelitis

Akkermansia muciniphila

Multiple sclerosis

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