Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release

Suofu, Yalikun; Li, Wěi; Jean‐Alphonse, Frédéric; Jia, Jiaoying; K. Khattar, Nicolas; Li, Jiatong; V. Baranov, Sergei; Leronni, Daniela; C. Mihalik, Amanda; He, Yanqing; Cecon, Erika; L. Wehbi, Vanessa; Kim, Jinho; Heath, Brianna; V. Baranova, Oxana; Wang, Xiaomin; Gable, Matthew; S. Kretz, Eric; Di Benedetto, Giulietta; R. Lezon, Timothy; M. Ferrando, Lisa; M. Larkin, Timothy; Sullivan, Mara; Yablonska, Svitlana; Wang, Jingjing; Beth Minnigh, M.; Guillaumet, Gérald; Suzenet, Franck; Mark Richardson, R.; M. Poloyac, Samuel; B. Stolz, Donna; Jockers, Ralf; A. Witt‐Enderby, Paula; L. Carlisle, Diane; Vilardaga, Jean‐Pierre; M. Friedlander, Robert

doi:10.1073/pnas.1705768114

Public

Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release

Published in Proceedings of the National Academy of Sciences • Sep 5, 2017

Authors:

Yalikun Suofu

Wěi Li

Frédéric Jean‐Alphonse

Abstract

Significance This paper describes the finding that mitochondria synthesize and release melatonin and have their selective G protein-coupled receptor (GPCR) in the outer membrane. We further demonstrate that mitochondrial melatonin type 1 receptors respond to melatonin by activating heterotrimeric G ...

Subject

G protein-coupled receptor

Melatonin

Cell biology

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