Tributylphosphate (TBP) and tris (2-butoxyethyl) phosphate (TBEP) induced apoptosis and cell cycle arrest in HepG2 cells

Ren, Guofa; Hu, Jingwen; Shang, Yu; Zhong, Yufang; Yu, Zhiqiang; An, Jing

doi:10.1039/c7tx00180k

Public

Tributylphosphate (TBP) and tris (2-butoxyethyl) phosphate (TBEP) induced apoptosis and cell cycle arrest in HepG2 cells

Published in Toxicology Research • Jan 1, 2017

Authors:

Guofa Ren

Jingwen Hu

Yu Shang

Abstract

The purpose of this study was to investigate the cytotoxic effects of tributylphosphate (TBP) and tris (2-butoxyethyl) phosphate (TBEP) and to explore the underlying molecular mechanism focusing on oxidative stress, apoptosis, and cell cycle arrest. The results showed that TBP and TBEP could inhibit...

Subject

Tris

Apoptosis

Cell cycle checkpoint

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