Deep gray matter volume loss drives disability worsening in multiple sclerosis

Eshaghi, Arman; Prados, Ferran; J. Brownlee, Wallace; R. Altmann, Daniel; Tur, Carmen; Jorge Cardoso, M.; De Angelis, Floriana; H. van de Pavert, Steven; Cawley, Niamh; De Stefano, Nicola; Laura Stromillo, M.; Battaglini, Marco; Ruggieri, Serena; Gasperini, Claudio; Filippi, Massimo; A. Rocca, Maria; Rovira, Alex; Sastre‐Garriga, Jaume; Vrenken, Hugo; E. Leurs, Cyra; Killestein, Joep; Pirpamer, Lukas; Enzinger, Christian; Ourselin, Sebastien; A.M. Gandini Wheeler‐Kingshott, Claudia; Chard, Declan; J. Thompson, Alan; C. Alexander, Daniel; Barkhof, Frederik; Ciccarelli, Olga; behalf of the MAGNIMS study group, on

doi:10.1002/ana.25145

Public

Deep gray matter volume loss drives disability worsening in multiple sclerosis

Shared by NobleBlocks on Feb 1, 2018 • 12:00 AM UTC

Authors:

Arman Eshaghi

Ferran Prados

Wallace J. Brownlee

Abstract

Objective Gray matter (GM) atrophy occurs in all multiple sclerosis (MS) phenotypes. We investigated whether there is a spatiotemporal pattern of GM atrophy that is associated with faster disability accumulation in MS. Methods We analyzed 3,604 brain high‐resolution T1‐weighted magnetic resonance im...

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