Complement 3a receptor in dorsal horn microglia mediates pronociceptive neuropeptide signaling

Doolen, Suzanne; Cook, Jennifer; Riedl, Maureen; F. Kitto, Kelley; Kohsaka, Shinichi; N. Honda, Christopher; A. Fairbanks, Carolyn; K. Taylor, Bradley; Vulchanova, Lucy

doi:10.1002/glia.23208

Public

Complement 3a receptor in dorsal horn microglia mediates pronociceptive neuropeptide signaling

Published in Glia • Aug 29, 2017

Authors:

Suzanne Doolen

Jennifer Cook

Maureen Riedl

Abstract

The complement 3a receptor (C3aR1) participates in microglial signaling under pathological conditions and was recently shown to be activated by the neuropeptide TLQP-21. We previously demonstrated that TLQP-21 elicits hyperalgesia and contributes to nerve injury-induced hypersensitivity through an u...

Subject

Microglia

Neuroscience

Neuropeptide

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