A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome

Khan, Akram; Benthin, Cody; Zeno, Brian; E. Albertson, Timothy; H. Boyd, John; D. Christie, Jason; Hall, Richard; Poirier, Germain; J. Ronco, Juan; Tidswell, Mark; Hardes, Kelly; Powley, William; J. Wright, Tracey; Siederer, Sarah; Fairman, David; A. Lipson, David; I. Bayliffe, Andrew; L. Lazaar, Aili

doi:10.1186/s13054-017-1823-x

Public

A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome

Published in Critical Care • Sep 6, 2017

Authors:

Akram Khan

Cody Benthin

Brian Zeno

Abstract

BACKGROUND: Renin-angiotensin system (RAS) signaling and angiotensin-converting enzyme 2 (ACE2) have been implicated in the pathogenesis of acute respiratory distress syndrome (ARDS). We postulated that repleting ACE2 using GSK2586881, a recombinant form of human angiotensin-converting enzyme 2 (rhA...

Subject

Medicine

ARDS

Placebo

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