A 13-gene expression-based radioresistance score highlights the heterogeneity in the response to radiation therapy across HPV-negative HNSCC molecular subtypes

Foy, Jean‐Philippe; Bazire, Louis; Ortiz‐Cuaran, Sandra; Deneuve, Sophie; Kielbassa, Janice; Thomas, Emilie; Viari, Alain; Puisieux, Alain; Goudot, P.; Bertolus, Chloé; Foray, Nicolas; Kirova, Youlia; Verrelle, Pierre; Saintigny, Pierre

doi:10.1186/s12916-017-0929-y

Public

A 13-gene expression-based radioresistance score highlights the heterogeneity in the response to radiation therapy across HPV-negative HNSCC molecular subtypes

Published in BMC Medicine • Aug 31, 2017

Authors:

Jean‐Philippe Foy

Louis Bazire

Sandra Ortiz‐Cuaran

Abstract

BACKGROUND: Radiotherapy for head and neck squamous cell carcinomas (HNSCC) is associated with a substantial morbidity and inconsistent efficacy. Human papillomavirus (HPV)-positive status is recognized as a marker of increased radiosensitivity. Our goal was to identify molecular markers associated ...

Subject

Radioresistance

Medicine

Radiation therapy

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