Mesenchymal Stromal Cell Exosomes Ameliorate Experimental Bronchopulmonary Dysplasia and Restore Lung Function through Macrophage Immunomodulation

R. Willis, Gareth; Fernandez‐Gonzalez, Angeles; N. Anastas, Jamie; Vitali, Sally; Liu, Xianlan; Ericsson, Maria; Kwong, April; Alex Mitsialis, S.; Kourembanas, Stella

doi:10.1164/rccm.201705-0925oc

Public

Mesenchymal Stromal Cell Exosomes Ameliorate Experimental Bronchopulmonary Dysplasia and Restore Lung Function through Macrophage Immunomodulation

Published in American Journal of Respiratory and Critical Care Medicine • Aug 30, 2017

Authors:

Gareth R. Willis

Angeles Fernandez‐Gonzalez

Jamie N. Anastas

Abstract

RATIONALE: Mesenchymal stem/stromal cell (MSC) therapies have shown promise in preclinical models of pathologies relevant to newborn medicine, such as bronchopulmonary dysplasia (BPD). We have reported that the therapeutic capacity of MSCs is comprised in their secretome, and demonstrated that the t...

Subject

Medicine

Mesenchymal stem cell

Bronchopulmonary dysplasia

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