Early Detection of Molecular Residual Disease in Localized Lung Cancer by Circulating Tumor DNA Profiling

A. Chaudhuri, Aadel; J. Chabon, Jacob; F. Lovejoy, Alexander; M. Newman, Aaron; Stehr, Henning; D. Azad, Tej; S. Khodadoust, Michael; Shahrokh Esfahani, Mohammad; Long Liu, Chih; Zhou, Li; Scherer, Florian; M. Kurtz, David; Say, Carmen; N. Carter, Justin; J. Merriott, David; C. Dudley, Jonathan; S. Binkley, Michael; Modlin, L.A.; K. Padda, Sukhmani; F. Gensheimer, Michael; B. West, Robert; B. Shrager, Joseph; W. Neal, Joel; A. Wakelee, Heather; W. Loo, Billy; A. Alizadeh, Ash; Diehn, Maximilian

doi:10.1158/2159-8290.cd-17-0716

Public

Early Detection of Molecular Residual Disease in Localized Lung Cancer by Circulating Tumor DNA Profiling

Published in Cancer Discovery • Sep 12, 2017

Authors:

Aadel A. Chaudhuri

Jacob J. Chabon

Alexander F. Lovejoy

Abstract

Abstract Identifying molecular residual disease (MRD) after treatment of localized lung cancer could facilitate early intervention and personalization of adjuvant therapies. Here, we apply cancer personalized profiling by deep sequencing (CAPP-seq) circulating tumor DNA (ctDNA) analysis to 255 sampl...

Subject

Medicine

Circulating tumor DNA

Lung cancer

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