Genetic and epigenetic features direct differential efficiency of Xist-mediated silencing at X-chromosomal and autosomal locations

Loda, Agnese; Brandsma, J; Vassilev, Ivaylo; Servant, Nicolas; Loos, Friedemann; Amirnasr, Azadeh; Splinter, Erik; Barillot, Emmanuel; A. Poot, Raymond; Heard, Édith; Gribnau, Joost

doi:10.1038/s41467-017-00528-1

Public

Genetic and epigenetic features direct differential efficiency of Xist-mediated silencing at X-chromosomal and autosomal locations

Published in Nature Communications • Sep 19, 2017

Authors:

Agnese Loda

J Brandsma

Ivaylo Vassilev

Abstract

Xist is indispensable for X chromosome inactivation. However, how Xist RNA directs chromosome-wide silencing and why some regions are more efficiently silenced than others remains unknown. Here, we explore the function of Xist by inducing ectopic Xist expression from multiple different X-linked and ...

Subject

XIST

X-inactivation

Biology

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