Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling

E. G. de Araújo, Mariana; Naschberger, Andreas; G. Fürnrohr, Barbara; Stasyk, Taras; Dunzendorfer-Matt, Theresia; Lechner, Stefan; Welti, Stefan; Kremser, Leopold; Shivalingaiah, Giridhar; Offterdinger, Martin; Lindner, Herbert; A. Huber, Lukas; Scheffzek, Klaus

doi:10.1126/science.aao1583

Public

Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling

Published in Science • Sep 22, 2017

Authors:

Mariana E. G. de Araújo

Andreas Naschberger

Barbara G. Fürnrohr

Abstract

The LAMTOR [late endosomal and lysosomal adaptor and MAPK (mitogen-activated protein kinase) and mTOR (mechanistic target of rapamycin) activator] complex, also known as "Ragulator," controls the activity of mTOR complex 1 (mTORC1) on the lysosome. The crystal structure of LAMTOR consists of two roa...

Subject

mTORC1

Guanosine

Cell biology

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