Clinical trial protocol for TRANSFORM‐UK: A therapeutic open‐label study of tocilizumab in the treatment of pulmonary arterial hypertension

Hernández‐Sánchez, Jules; Harlow, Louise; Church, Colin; Gaine, Seán; Knightbridge, Emily; Bunclark, Kate; Gor, Dee; Bedding, Alun; W. Morrell, Nicholas; A. Corris, Paul; Toshner, Mark

doi:10.1177/2045893217735820

Public

Clinical trial protocol for TRANSFORM‐UK: A therapeutic open‐label study of tocilizumab in the treatment of pulmonary arterial hypertension

Published in Pulmonary Circulation • Sep 28, 2017

Authors:

Jules Hernández‐Sánchez

Louise Harlow

Colin Church

Abstract

Our aim is to assess the safety and potential efficacy of a novel treatment paradigm in pulmonary arterial hypertension (PAH), immunomodulation by blocking interleukin-6 (IL6) signaling with the IL6 receptor antagonist, tocilizumab. Inflammation and autoimmunity are established as important in PAH p...

Subject

Tocilizumab

Medicine

Rheumatoid arthritis

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