Stem cell-derived neurons from autistic individuals with SHANK3 mutation show morphogenetic abnormalities during early development

Shank3 is a structural protein found predominantly at the postsynaptic density. Mutations in the SHANK3 gene have been associated with risk for autism spectrum disorder (ASD). We generated induced pluripotent stem cells (iPSCs) from control individuals and from human donors with ASD carrying microde... View More