Detection of known and novel ALK fusion transcripts in lung cancer patients using next-generation sequencing approaches

Abstract Rearrangements of the anaplastic lymphoma kinase ( ALK ) gene in non-small cell lung cancer (NSCLC) represent a novel molecular target in a small subset of tumors. Although ALK rearrangements are usually assessed by immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH), m... View More