A molecular mechanism for IL-4 suppression of loricrin transcription in epidermal keratinocytes: implication for atopic dermatitis pathogenesis

Bao, Lei; C Mohan, Girish; B Alexander, Jaime; Doo, Caroline; Shen, Kui; Bao, Jeremy; S Chan, Lawrence

doi:10.1177/1753425917732823

Public

A molecular mechanism for IL-4 suppression of loricrin transcription in epidermal keratinocytes: implication for atopic dermatitis pathogenesis

Shared by NobleBlocks on Sep 27, 2017 • 12:00 AM UTC

Authors:

Lei Bao

Girish C Mohan

Jaime B Alexander

Abstract

Skin barrier defects play an important role in atopic dermatitis (AD) pathogenesis. Loricrin, an important barrier protein suppressed in human AD, is down-regulated by IL-4 in keratinocytes. However, the molecular mechanism is unknown. Since loricrin transcription requires p300/CBP, and Stat6 also r...

Discussions