Activating α7 nicotinic acetylcholine receptor inhibits NLRP3 inflammasome through regulation of β-arrestin-1.

P, Ke; BZ, Shao; ZQ, Xu; XW, Chen; W, Wei; C, Liu

doi:10.1111/cns.12758

Public

Activating α7 nicotinic acetylcholine receptor inhibits NLRP3 inflammasome through regulation of β-arrestin-1.

Shared by NobleBlocks on Sep 21, 2017 • 12:00 AM UTC

Authors:

Ke P

Shao BZ

Xu ZQ

Abstract

Aims To evaluate whether activating α7 nicotinic acetylcholine receptor (α7nAChR) could inhibit the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome through regulation of β-arrestin-1 in monocyte/macrophage system, thus contributing to the control of neuroinflammation.Methods...

Subject

α7nAChR

neuroinflammation

Nlrp3 Inflammasome

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