Genetic effects on gene expression across human tissues

Aguet, François; V. Segrè, Ayellet; B. Cummings, Beryl; Gelfand, Ellen; Hadley, Kane; H. Huang, Katherine; Lek, Monkol; Li, Xiao; L. Nedzel, Jared; Y. Nguyen, Duyen; S. Noble, Michael; J. Sullivan, Timothy; Tukiainen, Taru; G. MacArthur, Daniel; Gs, Getz; Quon, Gerald; Zhang, Hailei; Kellis, Manolis; G. Ardlie, Kristin; A. Brown, Andrew; Delaneau, Olivier; Ongen, Halit; T. Dermitzakis, E.; E. Castel, Stephane; Mohammadi, P; Lappalainen, Tuuli; R. Davis, Joe; Zappala, Zachary; S. Abell, Nathan; C. Shimko, Tyler; A. Teran, Nicole; Cd, Bustamante; B. Montgomery, Stephen; Balliu, Brunilda; Frésard, Laure; J. Gloudemans, Michael; Li, Xin; Liu, Boxiang; K. Tsang, Emily; He, Yuan; J. Strober, Benjamin; Jo, Brian; DH Gewirtz, Ariel; Park, YoSon; K Brown, C; Parsana, Princy; Z. He, Amy; Saha, Ashis; Battle, Alexis; Ripke, S; M. Addington, Anjene; Koester, Susan; Pz, Guan; M. Moore, Helen; Rao, Abhi; A. Branton, Philip; Roger Little, A.; C. Lockhart, Nicole; P. Struewing, Jeffery; Volpi, Simona; E. Brigham, Lori; Hasz, Richard; Hunter, Marcus; Myer, Kevin; Roe, Bryan; Johns, Christopher; Wheeler, Joseph; Johnson, Mark; Walters, Gary; Washington, Michael; Kopen, Gene; F. Leinweber, William; Jd, Lonsdale; McDonald, Alisa; Mestichelli, Bernadette; Salvatore, Michael; Shad, Saboor; A. Thomas, Jeffrey; Bridge, Jason; Miklos, Mark; A. Foster, Barbara; M. Gillard, Bryan; Karasik, Ellen; Kumar, Rachna; T. Moser, Michael; D. Jewell, Scott; G. Montroy, Robert; C. Rohrer, Daniel; Valley, Dana; C. Mash, Deborah; Da, Davis; Sobin, Leslie; E. Barcus, Mary; R. Gamazon, Eric; J. Cox, Nancy; Garrido-Martín, Diego; Guigó, R; Gliner, Genna; Han, Buhm; Hormozdiari, F.; Eskin, Eleazar; Yong Kang, Eun; C. McDowell, Ian; Palowitch, John; B. Nobel, Andrew; B. Peterson, Christine; Av, Shabalin; Hoon Sul, Jae; Zhou, Yi-Hui; Sabatti, Chiara; I. McCarthy, Mark; F. Conrad, Donald; Li, Gen; E. Stranger, Barbara; Wen, Xiaoquan; A. Wright, Fred; E. Engelhardt, Barbara; E. Handsaker, Robert; Kashin, Seva; J. Karczewski, Konrad; T. Nguyen, Duyen; A. Trowbridge, Casandra; Claussnitzer, Melina; Hou, Lei; Liu, Yaping; Molinié, Benoit; Park, Yongsu; Rinaldi, N; Wang, Li; Van Wittenberghe, Nicholas; Chan, Joanne; Jian, Ruiqi; Jiang, Lihua; Billy Li, Jin; Li, Qin; Y. Lin, J.; Lin, Shin; Linder, Sandra; S. Smith, Kevin; P. Snyder, Michael; Tang, Hua; Wang, M; Zhang, Rui; Barshir, Ruth; Basha, Omer; Yeger‐Lotem, Esti; N. Damani, Farhan; Kim, Yungil; K. Bogu, Gireesh; Guigó, R; Monlong, Jean; Muñoz-Aguirre, Manuel; Papasaikas, Panagiotis; Reverter, Ferran; Sodaei, Reza; Brown, Andrew; Howald, Cédric; Panousis, Nikolaos; Kim-Hellmuth, Sarah; Chen, Lin; Demanelis, Kathryn; Jasmine, Farzana; G. Kibriya, Muhammad; L. Pierce, Brandon; Chiang, Colby; M. Hall, Ira; J. Scott, Alexandra; Mangul, Serghei; G. Ferreira, Pedro; DH Gewirtz, Ariel; M. Akey, Joshua; P. Feinberg, Andrew; Kyung Im, Hae; Nicolae, D; Oliva, Meritxell; S. Fernando, Marian; Linke, Caroline; Skol, Andrew; Wu, Fan; W. Ndungu, Anne; J. Payne, A.; van de Bunt, Martijn; Stephens, Matthew; Urbut, Sarah; Wang, Gao; Quan, Jie; S. Xi, Hualin; Sammeth, Michael; B. Zaugg, Judith; Bates, Daniel; Diegel, Morgan; Halow, Jessica; Haugen, Eric; Johnson, Audra; Kaul, Rajinder; Lee, Kristen; Nelson, Jemma; J. Neri, Fidencio; Sandström, R; A Stamatoyannopoulos, J; A Doherty, Jennifer; D. Hansen, Kasper; F. Rizzardi, Lindsay; F. Hickey, Peter; T. Maurano, Matthew; R. Nierras, Concepcion; J. Carithers, Latarsha; B. Vaught, Jimmie; E. Gould, Sarah; C. Lockart, Nicole; Martin, Casey; M. Addington, Anjene; E. Koester, Susan; Roe, Brian; R. Valley, Dana; H. Undale, Anita; M. Smith, Anna; E. Tabor, David; Roche, Nancy; A. McLean, Jeffrey; Vatanian, Negin; Robinson, Karna; M. Valentino, Kimberly; Qi, Liqun; Hunter, Steven; Hariharan, Pushpa; Singh, Shilpi; Sung Um, Ki; Matose, Takunda; Tomaszewski, M.; K. Barker, Laura; A. Siminoff, Laura; M. Traino, Heather; Mosavel, Maghboeba; Flicek, P; Juettemann, Thomas; Ruffier, Magali; Sheppard, Dan; Taylor, Kieron; J. Trevanion, Stephen; R. Zerbino, Daniel; Craft, Brian; Goldman, Mary; Haeussler, Maximilian; James Kent, W.; M. Lee, Christopher; Paten, Benedict; R. Rosenbloom, Kate; Jc, Vivian; Zhu, Jingchun

doi:10.1038/nature24277

Public

Genetic effects on gene expression across human tissues

Published in Nature • Oct 10, 2017

Authors:

François Aguet

Ayellet V. Segrè

Beryl B. Cummings

Abstract

Characterization of the molecular function of the human genome and its variation across individuals is essential for identifying the cellular mechanisms that underlie human genetic traits and diseases. The Genotype-Tissue Expression (GTEx) project aims to characterize variation in gene expression le...

Subject

Gene expression

Gene

Biology

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