Brain Oxygen Optimization in Severe Traumatic Brain Injury Phase-II: A Phase II Randomized Trial.

O Okonkwo, David; A Shutter, Lori; Moore, Carol; R Temkin, Nancy; M Puccio, Ava; J Madden, Christopher; Andaluz, Norberto; M Chesnut, Randall; Ross Bullock, M; A Grant, Gerald; McGregor, John; Weaver, Michael; Jallo, Jack; D LeRoux, Peter; Moberg, Dick; Barber, Jason; Lazaridis, Christos; R Diaz-Arrastia, Ramon

doi:10.1097/ccm.0000000000002619

Public

Brain Oxygen Optimization in Severe Traumatic Brain Injury Phase-II: A Phase II Randomized Trial.

Published in Critical care medicine • Nov 1, 2017

NobleIDark:/48914/w1/20260526/389080F4Record on NobleID

Authors:

David O Okonkwo

,

Lori A Shutter

,

Carol Moore

Abstract

OBJECTIVES: A relationship between reduced brain tissue oxygenation and poor outcome following severe traumatic brain injury has been reported in observational studies. We designed a Phase II trial to assess whether a neurocritical care management protocol could improve brain tissue oxygenation leve...

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