HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients

Guo, Wenting; Naujock, Maximilian; Fumagalli, Laura; Vandoorne, Tijs; Baatsen, Pieter; Boon, Ruben; Ordovás, Laura; Patel, Abdulsamie; Welters, Marc; Vanwelden, Thomas; Geens, Natasja; Tricot, Tine; Benoy, Veronick; Steyaert, Jolien; Lefebvre-Omar, Cynthia; Boesmans, Werend; Jarpe, Matthew; Sterneckert, Jared; Wegner, Florian; Petri, Susanne; Bohl, Delphine; Vanden Berghe, Pieter; Robberecht, Wim; Van Damme, Philip; Verfaillie, Catherine; Van Den Bosch, Ludo

doi:10.1038/s41467-017-00911-y

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HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients

Shared by NobleBlocks on Oct 11, 2017 • 12:00 AM UTC

Authors:

Wenting Guo

Maximilian Naujock

Laura Fumagalli

Abstract

Abstract Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder due to selective loss of motor neurons (MNs). Mutations in the fused in sarcoma ( FUS ) gene can cause both juvenile and late onset ALS. We generated and characterized induced pluripotent stem cells (iPS...

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