HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients

Guo, Wenting; Naujock, Maximilian; Fumagalli, Laura; Vandoorne, Tijs; Baatsen, Pieter; Boon, Ruben; Ordovás, Laura; Patel, Abdulsamie; Welters, Marie; Vanwelden, Thomas; Geens, Natasja; Tricot, Tine; Benoy, Veronick; Steyaert, Jolien; Lefebvre-Omar, Cynthia; Boesmans, Werend; Jarpe, Matthew; Sterneckert, Jared; Wegner, Florian; Petri, Susanne; Bohl, Delphine; Vanden Berghe, Pieter; Robberecht, Wim; Van Damme, Philip; M. Verfaillie, Catherine; Van Den Bosch, Ludo

doi:10.1038/s41467-017-00911-y

Public

HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients

Published in Nature Communications • Oct 5, 2017

Authors:

Wenting Guo

Maximilian Naujock

Laura Fumagalli

Abstract

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder due to selective loss of motor neurons (MNs). Mutations in the fused in sarcoma (FUS) gene can cause both juvenile and late onset ALS. We generated and characterized induced pluripotent stem cells (iPSCs) from AL...

Subject

Induced pluripotent stem cell

Amyotrophic lateral sclerosis

Axoplasmic transport

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