Effect of isoniazid preventive therapy on risk of death in west African, HIV-infected adults with high CD4 cell counts: long-term follow-up of the Temprano ANRS 12136 trial

Badje, Anani; Moh, Raoul; Gabillard, Delphine; Guéhi, Calixte; Kabran, Mathieu; Ntakpé, Jean-Baptiste; Le Carrou, Jérôme; Menan Kouamé, Gérard; Ouattara, Éric; Messou, Eugène; Anzian, Amani; Minga, Albert; Gnokoro, Joachim; Gouesse, Patrice; Emième, Arlette; Toni, Thomas-d'Aquin; Rabe, Cyprien; Sidibé, Baba; Nzunetu, Gustave; Dohoun, Lambert; Abo, Yao; Kamagate, Synali; Amon, Solange; Kouame, Amadou-Barenson; Koua, Aboli; Kouamé, Emmanuel; Daligou, Marcelle; Hawerlander, Denise; Ackoundzé, Simplice; Koule, Serge; Séri, Jonas; Ani, Alex; Dembélé, Fassery; Koné, Fatoumata; Oyebi, Mykayila; Mbakop, Nathalie; Makaila, Oyewole; Babatunde, Carolle; Babatunde, Nathaniel; Bleoué, Gisèle; Tchoutedjem, Mireille; Kouadio, Alain-Claude; Sena, Ghislaine; Yededji, Sahinou-Yediga; Karcher, Sophie; Rouzioux, Christine; Kouame, Abo; Assi, R.; Bakayoko, A.S.; K Domoua, Serge; Deschamps, Nina; Aka, Kakou; N’Dri-Yoman, Thérèse; Salamon, Roger; Journot, Valérie; Ahibo, Hughes; Ouassa, Timothée; Menan, Hervé; Inwoley, André; Danel, Christine; Eholié, Serge; Anglaret, Xavier; Badje, Anani; Moh, Raoul; Gabillard, Delphine; Guéhi, Calixte; Kabran, Mathieu; Ntakpé, Jean-Baptiste; Le Carrou, Jérôme; Menan Kouamé, Gérard; Ouattara, Éric; Messou, Eugène; Anzian, Amani; Minga, Albert; Gnokoro, Joachim; Gouesse, Patrice; Emième, Arlette; Toni, Thomas-d'Aquin; Rabe, Cyprien; Sidibé, Baba; Nzunetu, Gustave; Dohoun, Lambert; Abo, Yao; Kamagate, Synali; Amon, Solange; Kouame, Amadou-Barenson; Koua, Aboli; Kouamé, Emmanuel; Daligou, Marcelle; Hawerlander, Denise; Ackoundzé, Simplice; Koule, Serge; Séri, Jonas; Ani, Alex; Dembélé, Fassery; Koné, Fatoumata; Oyebi, Mykayila; Mbakop, Nathalie; Makaila, Oyewole; Babatunde, Carolle; Babatunde, Nathaniel; Bleoué, Gisèle; Tchoutedjem, Mireille; Kouadio, Alain-Claude; Sena, Ghislaine; Yededji, Sahinou-Yediga; Karcher, Sophie; Rouzioux, Christine; Kouame, Abo; Assi, R.; Bakayoko, A.S.; K Domoua, Serge; Deschamps, Nina; Aka, Kakou; N’Dri-Yoman, Thérèse; Salamon, Roger; Journot, Valérie; Ahibo, Hughes; Ouassa, Timothée; Menan, Hervé; Inwoley, André; Ndja, Ben-Ahoussi; Adou, Blandine; Kanga, Constance; Aoussi, E.; Bissagnené, E.; Ba-Gomis, Olivier; Zike, Yves-Alain; Akakpo, Claude; Sassan‐Morokro, Madeleine; P Mobio, M; Doféré, Bamba; Mesmin, Koman; Attia, Alain; Kouamé Mahassadi, Alassan; Horo, Apollinaire; Oussou, A; Chaix, Marie‐Laure; Peytavin, Gilles; Koné, Mariatou; N'Guessan, Kouamé; Fassassi, Raïmi; Niangoran, Serge; Desgrées du Loû, Annabel; Lert, France; Dray‐Spira, Rosemary; Jean, Kévin; Konan, Romuald; Bohoussou, Franck; Yao-Yapi, Cyril; N'guessan-Koffi, Larissa; Siloué, Bertine; Cissé, Adoulaye; Aboua, Adrienne; Konan, Sylvie; Kouamé, Antoine; N’Chot, Célestin; Amani, Elvis; Clouet, Gwenaëlle; Debono, Bruno; Chêne, Geneviève; Dosso, Mireille; Girard, Pierre‐Marie; Jarlier, Vincent; Masumbuko, Jean-Marie; Perronne, Christian; Sow, P.S.; Danel, Christine; Eholié, Serge‐Paul; Anglaret, Xavier

doi:10.1016/s2214-109x(17)30372-8

Public

Effect of isoniazid preventive therapy on risk of death in west African, HIV-infected adults with high CD4 cell counts: long-term follow-up of the Temprano ANRS 12136 trial

Published in The Lancet Global Health • Oct 12, 2017

Authors:

Anani Badje

Raoul Moh

Delphine Gabillard

Abstract

BACKGROUND: Temprano ANRS 12136 was a factorial 2 × 2 trial that assessed the benefits of early antiretroviral therapy (ART; ie, in patients who had not reached the CD4 cell count threshold used to recommend starting ART, as per the WHO guidelines that were the standard during the study period) and ...

Subject

Medicine

Antiretroviral therapy

Randomized controlled trial

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