Modulation of Renal GLUT2 by the Cannabinoid-1 Receptor: Implications for the Treatment of Diabetic Nephropathy

Hinden, Liad; Udi, Shiran; Drori, Adi; Gammal, Asaad; Nemirovski, Alina; Hadar, Rivka; Baraghithy, Saja; Permyakova, Anna; Geron, Matan; Cohen, Merav; Tsytkin-Kirschenzweig, Sabina; Riahi, Yael; Leibowitz, Gil; Nahmias, Yaakov; Priel, Avi; Tam, Joseph

doi:10.1681/asn.2017040371

Public

Modulation of Renal GLUT2 by the Cannabinoid-1 Receptor: Implications for the Treatment of Diabetic Nephropathy

Published in Journal of the American Society of Nephrology • Oct 13, 2017

Authors:

Liad Hinden

Shiran Udi

Adi Drori

Abstract

Export Altered glucose reabsorption via the facilitative glucose transporter 2 (GLUT2) during diabetes may lead to renal proximal tubule cell (RPTC) injury, inflammation, and interstitial fibrosis. These pathologies are also triggered by activating the cannabinoid-1 receptor (CB1R), which contribute...

Subject

GLUT2

Reabsorption

Diabetic nephropathy

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!