Why do
                    <scp>SGLT2</scp>
                    inhibitors reduce heart failure hospitalization?
                    <scp>A</scp>
                    differential volume regulation hypothesis

M. Hallow, Karen; Helmlinger, Gabriel; J. Greasley, Peter; J. V. McMurray, John; W. Boulton, David

doi:10.1111/dom.13126

Public

Why do SGLT2 inhibitors reduce heart failure hospitalization? A differential volume regulation hypothesis

Shared by NobleBlocks on Nov 15, 2017 • 12:00 AM UTC

Authors:

Karen M. Hallow

Gabriel Helmlinger

Peter J. Greasley

Abstract

The effect of a sodium glucose cotransporter 2 inhibitor (SGLT2i) in reducing heart failure hospitalization in the EMPA‐REG OUTCOMES trial has raised the possibility of using these agents to treat established heart failure. We hypothesize that osmotic diuresis induced by SGLT2 inhibition, a distinct...

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