Effect of Therapeutic Hypothermia Initiated After 6 Hours of Age on Death or Disability Among Newborns With Hypoxic-Ischemic Encephalopathy

R. Laptook, Abbot; Shankaran, Seetha; E. Tyson, Jon; Muñoz, Breda; F. Bell, Edward; N. Goldberg, Ronald; A. Parikh, Nehal; Ambalavanan, Namasivayam; Pedroza, Claudia; Pappas, Athina; Das, Abhik; S. Chaudhary, Aasma; A. Ehrenkranz, Richard; M. Hensman, Angelita; P. Van Meurs, Krisa; F. Chalak, Lina; M. Khan, Amir; E. G. Hamrick, Shannon; M. Sokol, Gregory; C. Walsh, Michele; B. Poindexter, Brenda; G. Faix, Roger; L. Watterberg, Kristi; D. Frantz, Ivan; Guillet, Ronnie; Devaskar, Uday; E. Truog, William; Y. Chock, Valerie; H. Wyckoff, Myra; C. McGowan, Elisabeth; P. Carlton, David; M. Harmon, Heidi; E. Brumbaugh, Jane; Michael Cotten, C.; J. Sánchez, Pablo; Maria Hibbs, Anna; D. Higgins, Rosemary

doi:10.1001/jama.2017.14972

Public

Effect of Therapeutic Hypothermia Initiated After 6 Hours of Age on Death or Disability Among Newborns With Hypoxic-Ischemic Encephalopathy

Published in JAMA • Oct 24, 2017

Authors:

Abbot R. Laptook

Seetha Shankaran

Jon E. Tyson

Abstract

Importance: Hypothermia initiated at less than 6 hours after birth reduces death or disability for infants with hypoxic-ischemic encephalopathy at 36 weeks' or later gestation. To our knowledge, hypothermia trials have not been performed in infants presenting after 6 hours. Objective: To estimate th...

Subject

Medicine

Hypothermia

Encephalopathy

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