Aristolochic acids and their derivatives are widely implicated in liver cancers in Taiwan and throughout Asia

Wei Tian Ng, Alvin; Ling Poon, Song; Ni Huang, Mi; Quan Lim, Jing; Boot, Arnoud; Yu, Willie; Suzuki, Yuka; Thangaraju, Saranya; Chuan Young Ng, Cedric; Tan, Patrick; Pang, See-Tong; Huang, Hao-Yi; Yu, Ming‐Chin; Lee, Po‐Huang; Hsieh, Sen‐Yung; Y. Chang, Alex; Tean Teh, Bin; Rozen, Steve

doi:10.1126/scitranslmed.aan6446

Public

Aristolochic acids and their derivatives are widely implicated in liver cancers in Taiwan and throughout Asia

Published in Science Translational Medicine • Oct 18, 2017

Authors:

Alvin Wei Tian Ng

Song Ling Poon

Mi Ni Huang

Abstract

and related plants, which contain nephrotoxins and mutagens in the form of aristolochic acids and similar compounds (collectively, AA). AA is implicated in multiple cancer types, sometimes with very high mutational burdens, especially in upper tract urothelial cancers (UTUCs). AA-associated kidney f...

Subject

HCCS

Aristolochia

Aristolochic acid

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