Association analysis identifies 65 new breast cancer risk loci

Michailidou, Kyriaki; Lindström, Sara; Dennis, Joe; Beesley, Jonathan; Hui, Shirley; Kar, Siddhartha; Lemaçon, Audrey; Soucy, Penny; M. Glubb, Dylan; Rostamianfar, Asha; K. Bolla, Manjeet; Wang, Qin; P. Tyrer, Jonathan; Dicks, Ed; Lee, Andrew; Wang, Zhaoming; Allen, Jamie; Keeman, Renske; Eilber, Ursula; D. French, Juliet; Qing Chen, Xiao; Fachal, Laura; McCue, Karen; E. McCart Reed, Amy; Ghoussaini, Maya; S. Carroll, Jason; Jiang, Xia; K. Finucane, Hilary; Adams, Marcia; A. Adank, Muriel; Ahsan, Habibul; Aittomäki, Kristiina; Anton‐Culver, Hoda; Antonenkova, Natalia; Arndt, Volker; J. Aronson, Kristan; Arun, Banu; L. Auer, Paul; Bacot, François; Barrdahl, Myrto; Baynes, Caroline; W. Beckmann, Matthias; Behrens, Sabine; Benı́tez, Javier; Bermisheva, Marina; Bernstein, Leslie; Blomqvist, Carl; Bogdanova, Natalia; E. Bojesen, Stig; Bonanni, Bernardo; Børresen‐Dale, Anne‐Lise; S. Brand, Judith; Brauch, Hiltrud; Brennan, Paul; Brenner, Hermann; A. Brinton, Louise; Broberg, Per; W. Brock, Ian; Broeks, Annegien; Brooks‐Wilson, Angela; Y. Brucker, Sara; Brüning, Thomas; Burwinkel, Barbara; Butterbach, Katja; Cai, Qiuyin; Cai, Hui; Caldés, Trinidad; Canzian, Federico; Carracedo, Ãngel; D. Carter, Brian; E. Castelao, Jose; Leung Chan, Tsun; David Cheng, Ting‐Yuan; Seng Chia, Kee; Choi, Ji‐Yeob; Christiansen, Hans; L. Clarke, Christine; Collaborators, NBCS; Collée, Margriet; Conroy, Don; Cordina‐Duverger, Emilie; Cornelissen, Sten; G. Cox, David; Cox, Angela; S. Cross, Simon; M. Cunningham, Julie; Czene, Kamila; B. Daly, Mary; Devilee, Peter; F. Doheny, Kimberly; Dörk, Thilo; dos‐Santos‐Silva, Isabel; Dumont, Martine; Durcan, Lorraine; Dwek, Miriam; M. Eccles, Diana; B. Ekici, Arif; Heather Eliassen, A.; Ellberg, Carolina; Elvira, Mingajeva; Engel, Christoph; Eriksson, Mikael; A. Fasching, Peter; D. Figueroa, Jonine; Flesch‐Janys, Dieter; Fletcher, Olivia; Flyger, Henrik; Fritschi, Lin; Gaborieau, Valérie; Gabrielson, Marike; Gago-Domínguez, Manuela; Gao, Yu‐Tang; M. Gapstur, Susan; Á. García-Sáenz, José; M. Gaudet, Mia; Georgoulias, V.; G. Giles, Graham; Glendon, Gord; S. Goldberg, Mark; E. Goldgar, David; González‐Neira, Anna; I.G. Alnæs, Grethe; Grip, Mervi; Gronwald, Jacek; Grundy, Anne; Guénel, Pascal; Haeberle, Lothar; Hahnen, Eric; A. Haiman, Christopher; Håkansson, Niclas; Hamann, Ute; Hamel, Nathalie; E. Hankinson, Susan; Harrington, Patricia; N. Hart, Steven; M. Hartikainen, Jaana; Hartman, Mikael; Hein, Alexander; Heyworth, Jane; Hicks, Belynda; Hillemanns, Peter; N. Ho, Dona; Hollestelle, Antoinette; J. Hooning, Maartje; N. Hoover, Robert; L. Hopper, John; Hou, Ming‐Feng; Hsiung, Chia‐Ni; Huang, Guanmengqian; Humphreys, Keith; Ishiguro, Junko; Ito, Hidemi; Iwasaki, Motoki; Iwata, Hiroji; Jakubowska, Anna; Janni, Wolfgang; M. John, Esther; Johnson, Nichola; Jones, Kristine; E. Jones, Michael; Jukkola‐Vuorinen, Arja; Kaaks, Rudolf; Kabisch, Maria; Kaczmarek, Katarzyna; Kang, Daehee; Kasuga, Yoshio; J. Kerin, Michael; Khan, Sofia; К. Хуснутдинова, Э.; I. Kiiski, Johanna; Kim, Sung-Won; A. Knight, Julia; Kosma, Veli‐Matti; N. Kristensen, Vessela; Krüger, Ute; Kwong, Ava; Lambrechts, Diether; Le Marchand, Loı̈c; Lee, Eunjung; Hyuk Lee, Min; Won Lee, Jong; Neng Lee, Chuen; Lejbkowicz, Flavio; Li, Jingmei; Lilyquist, Jenna; Lindblom, Annika; Lissowska, Jolanta; Lo, Wing‐Yee; Loibl, Sibylle; Long, Jirong; Lophatananon, Artitaya; Lubiński, Jan; Luccarini, Craig; P. Lux, Michael; S.K., Edmond; J. MacInnis, Robert; Maishman, Tom; Makalic, Enes; E. Malone, Kathleen; Maleva Kostovska, Ivana; Mannermaa, Arto; Manoukian, Siranoush; E. Manson, JoAnn; Margolin, Sara; Mariapun, Shivaani; Elena Martı́nez, Marı́a; Matsuo, Keitaro; Mavroudis, Dimitrios; McKay, James; McLean, Catriona; Meijers‐Heijboer, Hanne; Meindl, Alfons; Menéndez, Primitiva; Menon, Usha; Meyer, Jeffery; Miao, Hui; Miller, Nicola; Aishah Mohd Taib, Nur; Muir, Kenneth; Marie Mulligan, Anna; Mulot, Claire; L. Neuhausen, Susan; Nevanlinna, Heli; Neven, Patrick; F. Nielsen, Sune; Noh, Dong‐Young; G. Nordestgaard, Børge; D. Norman, Aaron; I. Olopade, Olufunmilayo; E. Olson, Janet; Olsson, Håkan; Olswold, Curtis; Orr, Nick; Shane Pankratz, V.; K. Park, Sue; Park‐Simon, Tjoung‐Won; Lloyd, Rachel; Ignacio Arias Pérez, José; Peterlongo, Paolo; Peto, Julian; Phillips, Kelly‐Anne; Pinchev, Mila; Plaseska‐Karanfilska, Dijana; L. Prentice, Ross; Presneau, Nadège; Prokofyeva, Darya; Pugh, Elizabeth; Pylkäs, Katri; Rack, Brigitte; Radice, Paolo; Rahman, Nazneen; Rennert, Gad; S. Rennert, Hedy; Rhenius, Valerie; Romero, Atocha; Romm, Jane; J. Ruddy, Kathryn; Rüdiger, Thomas; Rudolph, Anja; Ruebner, Matthias; J. Rutgers, Emiel; Saloustros, Emmanouil; P. Sandler, Dale; Sangrajrang, Suleeporn; J. Sawyer, Elinor; F. Schmidt, Daniel; K. Schmutzler, Rita; Schneeweiß, Andreas; J. Schoemaker, Minouk; R. Schumacher, Fredrick; Schürmann, Peter; J. Scott, Rodney; G. Scott, Christopher; Seal, Sheila; Seynaeve, Caroline; Shah, Mitul; Sharma, Priyanka; Shen, Chen‐Yang; Sheng, Grace; E. Sherman, Mark; J. Shrubsole, Martha; Shu, Xiao‐Ou; Smeets, Ann; Sohn, Christof; C. Southey, Melissa; J. Spinelli, John; Stegmaier, Christa; Stewart‐Brown, Sarah; Stone, Jennifer; O. Stram, Daniel; Surowy, Harald; J. Swerdlow, Anthony; M. Tamimi, Rulla; A. Taylor, Jack; Tengström, Maria; Teo, Soo‐Hwang; Beth Terry, Mary; C. Tessier, Daniel; Thanasitthichai, Somchai; Thöne, Kathrin; A.�E.�M. Tollenaar, Rob; Tomlinson, Ian; Tong, Ling; Torres, Diana; Truong, Thérèse; Tseng, Chiu-Chen; Tsugane, Shoichiro; Ulmer, Hans-Ulrich; Ursin, Giske; Untch, Michael; M. Vachon, Celine; J. van Asperen, Christi; Van Den Berg, David; M.W. van den Ouweland, Ans; van der Kolk, Lizet; B. van der Luijt, Rob; Vincent, Daniel; Vollenweider, Jason; Waisfisz, Quinten; Wang‐Gohrke, Shan; R. Weinberg, Clarice; Wendt, Camilla; S. Whittemore, Alice; Wildiers, Hans; C. Willett, Walter; Winqvist, Robert; Wolk, Alicja; H. Wu, Anna; Xia, Lucy; Yamaji, Taiki; R. Yang, Xiaohong; Har Yip, Cheng; Yoo, Keun-Young; Yu, Jyh‐Cherng; Zheng, Wei; Zheng, Ying; Zhu, Bin; Ziogas, Argyrios; Ziv, Elad; Investigators, ABCTB; Investigators, ConFab/AOCS; R. Lakhani, Sunil; C. Antoniou, Antonis; Droit, Arnaud; L. Andrulis, Irene; I. Amos, Christopher; J. Couch, Fergus; D.P. Pharoah, Paul; Chang‐Claude, Jenny; Hall, Per; J. Hunter, David; L. Milne, Roger; García‐Closas, Montserrat; K. Schmidt, Marjanka; J. Chanock, Stephen; M. Dunning, Alison; L. Edwards, Stacey; D. Bader, Gary; Chenevix‐Trench, Georgia; Simard, Jacques; Kraft, Peter; F. Easton, Douglas

doi:10.1038/nature24284

Public

Association analysis identifies 65 new breast cancer risk loci

Published in Nature • Oct 20, 2017

Authors:

Kyriaki Michailidou

Sara Lindström

Joe Dennis

Abstract

Association analysis identifies 65 new breast cancer risk loci, predicts target genes for known risk loci and demonstrates a strong overlap with somatic driver genes in breast tumours. Genome-wide association studies for breast cancer have identified common genetic variation that influences suscepti...

Subject

Breast cancer

Oncology

Association (psychology)

Research Assistant

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