SIRT1 Controls Acetaminophen Hepatotoxicity by Modulating Inflammation and Oxidative Stress

Rada, Patricia; Pardo, Virginia; A. Mobasher, Maysa; García-Martínez, Irma; Ruiz, Laura; González-Rodríguez, Águeda; Sanchez-Ramos, Cristina; Muntané, Jordi; Alemany, Susana; P. James, Laura; J. Simpson, Kenneth; Monsalve, María; Pilar Valdecantos, Maria; M. Valverde, Ángela

doi:10.1089/ars.2017.7373

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SIRT1 Controls Acetaminophen Hepatotoxicity by Modulating Inflammation and Oxidative Stress

Shared by NobleBlocks on May 1, 2018 • 12:00 AM UTC

Authors:

Patricia Rada

Virginia Pardo

Maysa A. Mobasher

Abstract

Aims: Sirtuin 1 (SIRT1) is a key player in liver physiology and a therapeutic target against hepatic inflammation. We evaluated the role of SIRT1 in the proinflammatory context and oxidative stress during acetaminophen (APAP)-mediated hepatotoxicity. Results: SIRT1 protein levels decreased in human ...

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