DsbA-L prevents obesity-induced inflammation and insulin resistance by suppressing the mtDNA release-activated cGAS-cGAMP-STING pathway

Significance Activation of the cGAMP-cGAS-STING pathway has recently been shown to mediate virus- or bacteria-induced activation of the innate immune response. Here we report that this pathway also plays an important role in obesity-induced inflammation and metabolic dysfunction, beyond its well-cha... View More