Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution

McGranahan, Nicholas; Rosenthal, Rachel; T. Hiley, Crispin; J. Rowan, Andrew; B.K. Watkins, Thomas; A. Wilson, Gareth; J. Birkbak, Nicolai; Veeriah, Selvaraju; Van Loo, Peter; Herrero, Javier; Swanton, Charles; Swanton, Charles; Jamal‐Hanjani, Mariam; Veeriah, Selvaraju; Shafi, Seema; Czyzewska-Khan, Justyna; Johnson, Diana; Laycock, Joanne; Bosshard‐Carter, Leticia; Rosenthal, Rachel; Gorman, Pat; E. Hynds, Robert; A. Wilson, Gareth; J. Birkbak, Nicolai; B.K. Watkins, Thomas; McGranahan, Nicholas; Horswell, Stuart; Mitter, Richard; Escudero, Mickael; Stewart, Aengus; Van Loo, Peter; Rowan, Andrew; Xu, Hang; Turajlic, Samra; T. Hiley, Crispin; Abbosh, Christopher; Goldman, Jacki; Stone, Richard; Denner, Tamara; Matthews, Nik; Elgar, Greg; Ward, Sophia; Costa, Marta; Begum, Sharmin; Phillimore, Ben; Chambers, Tim; Nye, Emma; Graca, Sofia; Al Bakir, Maise; Joshi, Kroopa; J.S. Furness, Andrew; Ben Aïssa, Assma; Ning Sophia Wong, Yien; Georgiou, Andy; A. Quezada, Sergio; A. Hartley, John; L. Lowe, Helen; Herrero, Javier; Lawrence, David; Hayward, Martin; Panagiotopoulos, Nikolaos; Kolvekar, Shyam; Falzon, Mary; Borg, Elaine; Marafioti, Teresa; Simeon, Celia; Hector, Gemma; Smith, Amy; Aranda, Marie; Novelli, Marco; Oukrif, Dahmane; M. Janes, Sam; M. Thakrar, Ricky; Förster, Martin; Ahmad, Tanya; Ming Lee, Siow; Papadatos-Pastos, Dionysis; Carnell, Dawn; Mendes, R.; George, Jeremy; Navani, Neal; Ahmed, Asia; N. Taylor, Magali; Choudhary, Junaid; Summers, Yvonne; Califano, Raffaele; W. J. Taylor, P.; Shah, Rajesh; Krysiak, Piotr; Rammohan, Kendadai; Fontaine, Eustace; Booton, Richard; Evison, Matthew; Crosbie, Philip; Moss, Stuart; Idries, Faiza; Dennis Joseph, Leena; Bishop, Paul; Chaturved, Anshuman; Marie Quinn, Anne; Doran, Helen; Leek, Angela; Harrison, Phil; Moore, Katrina; Waddington, Rachael; Novasio, Juliette; Blackhall, Fiona; Rogan, Jane; Smith, Elaine; Dive, Caroline; Tugwood, Jonathan; Brady, Ged; G. Rothwell, Dominic; Chemi, Francesca; Pierce, Jackie; Gulati, Sakshi; Naidu, Babu; Langman, Gerald; Trotter, Simon; Bellamy, Mary; Bancroft, Hollie; Kerr, Amy; Kadiri, Salma; Webb, Joanne; Middleton, Gary; Djearaman, Madava; A. Fennell, Dean; Shaw, Jacqui; Le Quesne, John; Moore, David; Nakas, Apostolos; Rathinam, Sridhar; Monteiro, William; Marshall, Hilary; Nelson, Louise; Bennett, Jonathan; Riley, Joan; Primrose, Lindsay; Martinson, Luke; Anand, Girija; Khan, Sajid; Amadi, Anita; Nicolson, M.; M. Kerr, Keith; Palmer, Shirley; Remmen, Hardy; Richard Miller, J.; Buchan, Keith; Chetty, Mahendran; Gomersall, Lesley; Lester, J.F.; Edwards, Alison; J. E. Morgan, Fiona; Adams, Haydn; Davies, Helen; Kornaszewska, Malgorzata; Attanoos, Richard; Lock, Sara; Verjee, Azmina; MacKenzie, Mairead; Wilcox, Maggie; Bell, Harriet; Hackshaw, Allan; Ngai, Yenting; Smith, Sean; Gower, Nicole; H. Ottensmeier, Christian; Chee, Serena; M. Johnson, Benjamin; Alzetani, Aiman; Shaw, Emily; Lim, Eric; De Sousa, Paulo; Tavares Barbosa, Monica; Bowman, Alex; Jordan, Simon; Rice, Alexandra; Raubenheimer, Hilgardt; Proli, Chiara; Elena Cufari, Maria; Carlo Ronquillo, John; Kwayie, Angela; Bhayani, Harshil; Hamilton, Morag; Bakar, Yusura; Mensah, Natalie; Ambrose, Lyn; Devaraj, Anand; Buderi, Silviu; Finch, Jonathan; Azcarate, Leire; Chavan, Hema; M. Green, Sophie; Mashinga, Hillaria; G. Nicholson, Andrew; Lau, Kelvin; Sheaff, Michael; Schmid, Peter; Conibear, John; Ezhil, Veni; Ismail, Babikir; Irvin-Sellers, Melanie; Prakash, Vineet; Russell, Peter; Light, Teresa; Horey, Tracey; Danson, Sarah; Bury, Jonathan; Edwards, John; Hill, Jennifer; Matthews, Sue; Kitsanta, Yota; Suvarna, Kim; Fisher, Patricia; Dino Keerio, Allah; Shackcloth, Michael; R. Gosney, John; E. Postmus, Pieter; Feeney, Sarah; Asante-Siaw, Julius; J.W.L. Aerts, Hugo; C. Dentro, Stefan; Dessimoz, Christophe

doi:10.1016/j.cell.2017.10.001

Public

Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution

Published in Cell • Oct 26, 2017

Authors:

Nicholas McGranahan

Rachel Rosenthal

Crispin T. Hiley

Abstract

Immune evasion is a hallmark of cancer. Losing the ability to present neoantigens through human leukocyte antigen (HLA) loss may facilitate immune evasion. However, the polymorphic nature of the locus has precluded accurate HLA copy-number analysis. Here, we present loss of heterozygosity in human l...

Subject

Biology

Allele

Immune system

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