lncRNA MIR100HG-derived miR-100 and miR-125b mediate cetuximab resistance via Wnt/β-catenin signaling

Lu, Yuanyuan; Zhao, Xiaodi; Liu, Qi; Li, Cunxi; Graves‐Deal, Ramona; Cao, Zheng; Singh, Bhuminder; L. Franklin, Jeffrey; Wang, Jing; Hu, Huaying; Wei, Tianying; Yang, Mingli; J. Yeatman, Timothy; Lee, Ethan; Saito‐Diaz, Kenyi; A. Hinger, Scott; G. Patton, James; H. Chung, Christine; Emmrich, Stephan; Klusmann, Jan‐Henning; Fan, Daiming; J. Coffey, Robert

doi:10.1038/nm.4424

Public

lncRNA MIR100HG-derived miR-100 and miR-125b mediate cetuximab resistance via Wnt/β-catenin signaling

Published in Nature Medicine • Oct 16, 2017

Authors:

Yuanyuan Lu

Xiaodi Zhao

Qi Liu

Abstract

Concomitant overexpression of microRNAs miR-100 and miR-125b-1 within the host long non-coding RNA MIR100HG induces cetuximab resistance in cancer in the absence of previously associated genetic alterations. miR-100 and miR-125b target negative regulators of Wnt/β-catenin signaling and sustain drug ...

Subject

Cetuximab

Wnt signaling pathway

Colorectal cancer

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