High grade serous ovarian carcinomas originate in the fallopian tube

Intidhar Labidi‐Galy, Sana; Papp, Eniko; Hallberg, Dorothy; Niknafs, Noushin; Adleff, Vilmos; Noë, Michaël; Bhattacharya, Rohit; Novak, Marián; Jones, Siân; Phallen, Jillian; Hruban, Carolyn; S. Hirsch, Michelle; I. Lin, Douglas; E. Schwartz, Lauren; L. Maire, Cécile; Tille, Jean‐Christophe; Bowden, Michaela; Ayhan, A.; D. Wood, Laura; B. Scharpf, Robert; J. Kurman, Robert; Wang, Tian-Li; Shih, Ie‐Ming; Karchin, Rachel; Drapkin, Ronny; E. Velculescu, Victor

doi:10.1038/s41467-017-00962-1

Public

High grade serous ovarian carcinomas originate in the fallopian tube

Published in Nature Communications • Oct 17, 2017

Authors:

Sana Intidhar Labidi‐Galy

Eniko Papp

Dorothy Hallberg

Abstract

High-grade serous ovarian carcinoma (HGSOC) is the most frequent type of ovarian cancer and has a poor outcome. It has been proposed that fallopian tube cancers may be precursors of HGSOC but evolutionary evidence for this hypothesis has been limited. Here, we perform whole-exome sequence and copy n...

Subject

Fallopian tube

Serous fluid

Ovary

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