Dimethyl Sulfoxide (DMSO) Decreases Cell Proliferation and TNF-α, IFN-γ, and IL-2 Cytokines Production in Cultures of Peripheral Blood Lymphocytes

de Abreu Costa, Lucas; Henrique Fernandes Ottoni, Marcelo; Dos Santos, Michaelle; Batista Meireles, Agnes; Gomes de Almeida, Valéria; de Fátima Pereira, Wagner; Alves Avelar-Freitas, Bethânia; Eustáquio Brito Alvim de Melo, Gustavo

doi:10.3390/molecules22111789

Public

Dimethyl Sulfoxide (DMSO) Decreases Cell Proliferation and TNF-α, IFN-γ, and IL-2 Cytokines Production in Cultures of Peripheral Blood Lymphocytes

Published in Molecules • Nov 10, 2017

Authors:

Lucas de Abreu Costa

Marcelo Henrique Fernandes Ottoni

Michaelle Dos Santos

Abstract

Dimethylsulfoxide (DMSO) is an amphipathic molecule composed of a polar domain characterized by the sulfinyl and two nonpolar methyl groups, for this reason it is able to solubilize polar and nonpolar substances and transpose hydrophobic barriers. DMSO is widely used to solubilize drugs of therapeut...

Subject

Peripheral blood mononuclear cell

Cytokine

Chemistry

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